,
a national effort to develop an implantable bioartificial kidney that
could eliminate the need for dialysis, announced a key milestone in a
November 7 presentation at the American Society of Nephrology Kidney
Week 2019 conference in Washington, DC. The project team reported that UC San Francisco scientists successfully
implanted a prototype kidney bioreactor containing functional human
kidney cells in large animals without significant safety concerns. The
device, which is about the size of a deck of cards, did not trigger an
immune reaction or cause blood clots, an important milestone on the road
to future human trials. “This is the first demonstration that kidney cells can be implanted
successfully without immunosuppression in preclinical models and remain
healthy enough to perform their function. This is a key milestone for us
on the way to clinical trials in humans,” said Shuvo Roy, PhD, a
faculty member in the Department of Bioengineering and Therapeutic
Sciences, a joint department of the UCSF Schools of Pharmacy and
Medicine. “Based on these results, we can now focus on scaling up the
bioreactor and combining it with the blood filtration component of the
artificial kidney." -->
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