Certain antidepressants linked to increased hip fracture risk for patients on hemodialysis

Researchers of a published study found both short- and long-term use of selective serotonin reuptake inhibitors was associated with increased risk for hip fracture among patients on hemodialysis.
“Antidepressants are frequently prescribed to manage anxiety and depression associated with advanced organ failure,” Chandan Vangala, MD, MS, of the section of nephrology at Baylor College of Medicine in Houston, and colleagues wrote. “Within the general population, antidepressants have been linked to increased fracture risk and, more specifically, selective serotonin reuptake inhibitors (SSRIs) have been associated with hip fractures. Effects on both bone metabolism and falls have been touted as potential mechanisms of increased risk. However, the bone pathology associated with kidney disease is both diverse and distinct from osteoporosis. Thus, the impact of SSRIs on hip fracture risk in maintenance dialysis patients remains unexplored.”--> READ MORE